OICC Press Journal of Nanostructure in Chemistry 2193-8865 13 1 (February 2023) 2022 03 01 Synthesis and characterization of cellulose, β-cyclodextrin, silk fibroin-based hydrogel containing copper-doped cobalt ferrite nanospheres and exploration of its biocompatibility 10.1007/s40097-022-00481-6 EN Reza Eivazzadeh-Keihan Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR Fatemeh Ganjali Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR Hooman Aghamirza Moghim Aliabadi Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IR Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, IR Ali Maleki Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IR Saeedeh Pouri Protein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, IR Mohammad Mahdavi Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IR Ahmed Esmail Shalan BCMaterials, Basque Center for Materials, Applications and Nanostructures, Martina Casiano, Leioa, 48940, ES Central Metallurgical Research and Development Institute (CMRDI), Helwan, Cairo, 11421, EG Senentxu Lanceros-Méndez BCMaterials, Basque Center for Materials, Applications and Nanostructures, Martina Casiano, Leioa, 48940, ES Basque Foundation for Science, IKERBASQUE, Bilbao, 48009, ES Journal Article 2022 03 01 Abstract A novel multifunctional biocomposite scaffold based on cellulose (Cel) and β-cyclodextrin (β.CD) biopolymers modified with extracted silk fibroin (SF) as well as magnetic copper-doped cobalt ferrite (CuCoFe 2 O 4 ) nanospheres has been developed. The hybrid scaffold was characterized by FE–SEM, TGA, FT–IR, and EDS techniques to demonstrate the core–shell morphology, thermal stability of the main structure, the chemical bonds as well as the good connections in the composite structure, and the good distribution of the particles in the formed structure, respectively. The Cel-β.CD/SF/CuCoFe 2 O 4 biocomposite shows a cell viability above 84% in addition to 80% after three and seven days, respectively, and low hemolytic effect (below 3%), which confirms a high hemocompatibility of this hydrogel. Further, the antibacterial property of the biocomposite was identified from superficial P. aeruginosa biofilm formation prevention. Thus, developed biocompatible hydrogel shows suitable characteristics for a variety of biomedical applications. Graphical abstract