OICC Press Journal of Nanostructure in Chemistry 2193-8865 12 5 (October 2022) 2021 09 12 Bio-conditioning poly-dihydromyricetin zinc nanoparticles synthesis for advanced catalytic degradation and microbial inhibition 10.1007/s40097-021-00443-4 EN Fan Luo School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Dandan Zeng School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Wenxiong Wang School of Energy and Environment and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, 999077, CN Research Centre for the Oceans and Human Health, City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, CN Yuanting Yang School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, 510225, CN Ayesha Zafar Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, 100871, CN Ziqian Wu School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Yubo Tian School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, 510225, CN Yunmao Huang School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, 510225, CN Murtaza Hasan School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Xugang Shu School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, 510225, CN Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, 510225, CN Journal Article 2021 09 12 Abstract An efficient bio-conditioning of the nanomaterial for microbial inhibition and catalytic degradation has been recognized as a promising solution to protect public health and environmental safety. Herein, a bio-conditioned poly-dihydromyricetin-fused zinc nanoparticles (PDMY-Zn NPs) were designed and constructed based on a green tonic approach, which displays excellent processing efficiency against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) as well as three dye effluents. Irregular-shaped PDMY-Zn NPs of size range 300–400 nm were formed by the undirected aggregation between Zn 2+ and dihydromyricetin (DMY) isolated from Ampelopsis grossedentata , contributing to the controlled release of Zn 2+ in gastrointestinal fluid. Such bio-conditioned nanomaterial relied on the stable and strong interaction between the bacterial membrane and carbohydrate polymeric DMY chain in PDMY-Zn NPs achieves a large amount of adhesion to both E. coli and S. aureus , which allows the targeted detachment of Zn 2+ from nanoparticles and accurate penetration into the pathogens, thereby achieving the nontoxicity to normal cells and minimizing drug-resistant bacteria. The division and spread of E. coli and S. aureus treated with PDMY-Zn NPs were effectively restricted and halted owing to multidimensional antibacterial behaviors of bacteriostatic agents, which are reflected in membrane damage, high cellular leakages and destroying intracellular ATP. Moreover, the designed PDMY-Zn NPs exhibit an efficient generation of hydroxyl (OH) and excess superoxide, which support it as a promising catalyst for photodegradation of methyl blue (93.02%), methyl orange (93.02%) and safranine (88.3%). Thus, this novel bio-conditioned nanomaterial provides a stable, nontoxic and advanced strategy to address drug-resistant bacteria infections as well as degradation of toxic dye effluents.