OICC Press Journal of Nanostructure in Chemistry 2193-8865 12 4 (August 2022) 2021 07 20 Low dimensional Bi2Se3 NPs/reduced graphene oxide nanocomposite for simultaneous detection of L-Dopa and acetaminophen in presence of ascorbic acid in biological samples and pharmaceuticals 10.1007/s40097-021-00428-3 EN Govinda Gorle Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, TW Ayyappa Bathinapatla Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, TW Department of Chemistry, Raghu Engineering College (Autonomous), Visakhapatnam, Andhra Pradesh, 531162, IN Suvardhan Kanchi Department of Chemistry, Durban University of Technology, Durban, 4000, ZA Department of Chemistry, Sambhram Institute of Technology, Bengaluru, 560097, IN Yong Chien Ling Department of Chemistry, National Tsing Hua University, Hsinchu, 30013, TW Mashallah Rezakazemi Faculty of Chemical and Materials Engineering, Shahrood University of Technology, Shahrood, IR Journal Article 2021 07 20 Abstract Graphene-based inorganic layered materials have developed as a versatile, new class of nanomaterials and drawn huge scientific interest, owing to its thickness-dependent physical properties, exfoliated two-dimensional crystals in various technological and industrial applications. This work is the first demonstration of the fabrication of low dimensional bismuth selenide (Bi 2 Se 3 ) NPs functionalized reduced graphene oxide (rGO) on the platinum electrode (Pt-E) for the ultra-sensitive and simultaneous detection of acetaminophen (ACT) and L-DOPA (LD) in the presence of ascorbic acid (AA) in various biological samples and pharmaceuticals. The constructed electrode accelerates the electron transfer reactions of LD and ACT without interfering with the electron transfer reactions of AA, which was an electroactive coexisting chemical. At pH 6.0 in 0.1 M phosphate buffer solution, Bi 2 Se 3 NPs/rGO/Pt-E showed a sixfold and fivefold increase in cyclic voltammetry for LD and ACT signals, respectively, when compared to bare Pt-E. Under the optimal conditions, differential pulse voltammetry (DPV) demonstrated that the anodic peak currents were linearly dependent on the concentrations of LD (0.006–0.25 mM) and ACT (0.0045–0.14 mM) at anodic peak potentials of + 0.25 and + 0.52 V, respectively. With a signal to noise (S/N) ratio of 3, acceptable detection limits of 0.23 and 0.17 M were achieved for both LD and ACT, with strong intra- and inter-electrode repeatability. Overall, the fabricated nanosensor offered numerous advantages including ease to fabricate, ultra-sensitivity, good stability, and reproducibility towards the detection of LD and ACT in various bioloical samples and pharmaceuticals. The amounts of LD and ACT were also identified in commercial pharmaceuticals and synthetic urine samples to validate the applicability of the modified electrode.