10.1007/s40097-018-0282-5

Electrosynthesis of nano-sized pyran and chromene derivatives by one-pot reaction between cyclic-1,3-diketons, malononitrile/ethyl cyanoacetate, and isatins

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  • Mohaddeseh Taheri1,
  • Behrooz Mirza*2,
  • Mohsen Zeeb1,
  1. Department of Science, South Tehran Branch, Islamic Azad University, Tehran, IR
  2. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, IR
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Published in Issue 20-10-2018

How to Cite

Taheri, M., Mirza, B., & Zeeb, M. (2018). Electrosynthesis of nano-sized pyran and chromene derivatives by one-pot reaction between cyclic-1,3-diketons, malononitrile/ethyl cyanoacetate, and isatins. Journal of Nanostructure in Chemistry, 8(4 (December 2018). https://doi.org/10.1007/s40097-018-0282-5
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Abstract

Abstract An efficient and sustainable method was developed for the electrocatalytic synthesis of nano-sized 4 H -pyran derivatives via a green, one-pot, three-component condensations of cyclic-1,3-diketones [including 1H-indene-1,3(2H)-dione, cyclohexane-1,3-dione, cyclopentane-1,3-dione, pyrimidine-2,4,6(1H,3H,5H)-trione], malononitrile or ethyl cyanoacetate, and isatins in an undivided electrochemically cell applying potassium bromide as the electrolyte in the alcoholic media. This electrosynthesis was introduced as a reliable and cost-effective approach for the high-yielding synthesis (76–92%) of the target compounds. The synthesized 4 H -pyran and chromene nanoparticles could open an effective way for production of nano-sized drugs. Graphical abstract

Keywords

  • Electrocatalytic three-component synthesis,
  • Nanoparticle,
  • Cyclic-1,
  • 3-diketones,
  • 1H-indene-1,3(2H)-dione,
  • Cyclohexane-1,3-dione,
  • Cyclopentane-1,3-dione,
  • Pyrimidine-2,4,6(1H,3H,5H)-trione,
  • Malononitrile,
  • Ethyl cyanoacetate,
  • Isatins,
  • 4H-:pyran
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References

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