10.1007/s40097-022-00514-0

Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery

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  • Nasim Khosravani1,
  • Vahid Ahmadi2,
  • Ali Kakanejadifard1,
  • Mohsen Adeli*1,
  1. Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad, 68151-44316, IR
  2. Institut für Chemie und Biochemie, Freie Universität Berlin, Berlin, 14195, DE
Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery

Published in Issue 30-09-2022

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Khosravani, N., Ahmadi, V., Kakanejadifard, A., & Adeli, M. (2022). Thermoresponsive and antibacterial two-dimensional polyglycerol-interlocked-polynipam for targeted drug delivery. Journal of Nanostructure in Chemistry, 14(3). https://doi.org/10.1007/s40097-022-00514-0
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Abstract

Abstract Two-dimensional polymeric networks are a new class of polymers with interesting physicochemical and biological properties. They promise a wide range of future biomedical applications including pathogen interactions, drug delivery, bioimaging, photothermal, and photodynamic therapy, owing to their unique features, such as high surface area and multivalent interactions at nano-biointerfaces. In this work, a thermosensitive two-dimensional polymeric network consisting poly( N -isopropylacrylamide) (pNIPAM) chains that are mechanically interlocked by a polyglycerol platform was synthesized and used for bacteria incapacitation. Two-dimensional hyperbranched polyglycerol (2D-hPG) was synthesized by a graphene-assisted strategy and used for encapsulation of azobisisobutyronitrile (AIBN). Radical polymerization of N -isopropylacrylamide by encapsulated AIBN resulted in thermoresponsive platforms with ~ 500 nm lateral size and 20–50 nm thickness. Due to its porous structure, 2D-PNPG was able to efficiently load antibiotics, such as tetracycline (TC) and amoxicillin (AMX). The rate of release of antibiotics from 2D-PNPG and the antibacterial activity of the system correlated with the variation of temperature as a result of the thermosensitivity of 2D-PNPG. This study shows that two-dimensional polymers are efficient platforms for future biomedical applications including drug delivery and bacteria incapacitation. Graphical abstract Thermoresponsive two-dimensional nanomaterials with the ability of loading therapeutic agents and antibacterial activity are synthesized and characterized.

Keywords

  • Antibacterial,
  • Two-dimensional,
  • Polyglycerol,
  • Thermoresponsive,
  • N-isopropylacrylamide

References

  1. Donskyi et al. (2019) Functionalized nanographene sheets with high antiviral activity through synergistic electrostatic and hydrophobic interactions 11(34) (pp. 15804-15809) https://doi.org/10.1039/C9NR05273A
  2. Tu et al. (2018) Multivalent interactions between 2D nanomaterials and biointerfaces 30(33) https://doi.org/10.1002/adma.201706709
  3. Tu et al. (2018) Directed graphene-based nanoplatforms for hyperthermia: overcoming multiple drug resistance 130(35) (pp. 11368-11372) https://doi.org/10.1002/ange.201804291
  4. Tan et al. (2018) Functionalized 2D nanomaterials with switchable binding to investigate graphene–bacteria interactions 10(20) (pp. 9525-9537) https://doi.org/10.1039/C8NR01347K
  5. Sattari et al. (2020) Boronic acid-functionalized two-dimensional MoS2 at biointerfaces 36(24) (pp. 6706-6715) https://doi.org/10.1021/acs.langmuir.0c00776
  6. Sattari et al. (2020) Fabrication of new generation of co-delivery systems based on graphene-g-cyclodextrin/chitosan nanofiber (pp. 1126-1134) https://doi.org/10.1016/j.ijbiomac.2019.11.144
  7. Beyranvand et al. (2020) Boronic acid functionalized graphene platforms for diabetic wound healing (pp. 327-336) https://doi.org/10.1016/j.carbon.2019.10.077
  8. Bhatia et al. (2021) Wrapping and Blocking of influenza A viruses by sialylated 2D nanoplatforms 8(12) https://doi.org/10.1002/admi.202100285
  9. Makvandi et al. (2019) Biosynthesis and characterization of antibacterial thermosensitive hydrogels based on corn silk extract, hyaluronic acid and nanosilver for potential wound healing https://doi.org/10.1016/j.carbpol.2019.115023
  10. Makvandi et al. (2020) Hyaluronic acid/corn silk extract based injectable nanocomposite: a biomimetic antibacterial scaffold for bone tissue regeneration https://doi.org/10.1016/j.msec.2019.110195
  11. Ghahremanloo et al. (2022) Electroconductive and photoactive poly (phenylenediamine) s with antioxidant and antimicrobial activities for potential photothermal therapy 46(13) (pp. 6255-6266) https://doi.org/10.1039/D1NJ06145C
  12. Moghaddam and Bertani (2022) Application of microfluidic platforms in cancer therapy 1(1) (pp. 69-88)
  13. Heidari et al. (2022) Biosynthesized nanomaterials with antioxidant and antimicrobial properties 1(1) (pp. 35-48)
  14. Ghanbari et al. (2022) Ionic liquid-based sensors (pp. 123-135)
  15. Sattari et al. (2018) pH-responsive hybrid hydrogels as antibacterial and drug delivery systems 10(6) https://doi.org/10.3390/polym10060660
  16. Zare et al. (2021) Nonspherical metal-based nanoarchitectures: synthesis and impact of size shape, and composition on their biological activity 17(17) https://doi.org/10.1002/smll.202007073
  17. Chen et al. (2018) Design of smart targeted and responsive drug delivery systems with enhanced antibacterial properties 10(45) (pp. 20946-20962) https://doi.org/10.1039/C8NR07146B
  18. Devnarain et al. (2021) Intrinsic stimuli-responsive nanocarriers for smart drug delivery of antibacterial agents—an in-depth review of the last two decades 13(1) https://doi.org/10.1002/wnan.1664
  19. Kang et al. (2019) Antibiotic delivery: in vitro and in vivo antimicrobial activity of antibiotic-conjugated carriers with rapid pH-responsive release kinetics (Adv. Healthcare Mater. 14/2019) 8(14) https://doi.org/10.1002/adhm.201970058
  20. Wieduwild et al. (2019) Engineering hydrogels beyond a hydrated network 8(14) https://doi.org/10.1002/adhm.201900038
  21. Sun et al. (2021) Near-infrared light triggered photodynamic and nitric oxide synergistic antibacterial nanocomposite membrane https://doi.org/10.1016/j.cej.2020.128049
  22. Liu et al. (2022) The bioanalytical and biomedical applications of polymer modified substrates 14(4) https://doi.org/10.3390/polym14040826
  23. Zhang et al. (2019) Recent advances in stimuli-responsive polymer systems for remotely controlled drug release https://doi.org/10.1016/j.progpolymsci.2019.101164
  24. Preman et al. (2020) Recent developments in stimuli-responsive polymer nanogels for drug delivery and diagnostics: a review (pp. 121-153) https://doi.org/10.1016/j.ejpb.2020.10.009
  25. Shi and Chen (2018) Function-driven design of stimuli-responsive polymer composites: recent progress and challenges 6(44) (pp. 11817-11834) https://doi.org/10.1039/C8TC02980F
  26. Vázquez-González and Willner (2020) Stimuli-responsive biomolecule-based hydrogels and their applications 59(36) (pp. 15342-15377) https://doi.org/10.1002/anie.201907670
  27. Sponchioni et al. (2019) Thermo-responsive polymers: applications of smart materials in drug delivery and tissue engineering (pp. 589-605) https://doi.org/10.1016/j.msec.2019.04.069
  28. Castillo-Henríquez et al. (2021) Exploration of bioengineered scaffolds composed of thermo-responsive polymers for drug delivery in wound healing 22(3) https://doi.org/10.3390/ijms22031408
  29. Arroub et al. (2021) Thermoresponsive poly (N-Isopropylacrylamide)/polycaprolacton nanofibrous scaffolds for controlled release of antibiotics 23(9) https://doi.org/10.1002/adem.202100221
  30. Bahara et al. (2021) Application of modified graphene oxide with thermosensitive polymers for adsorption of antibiotics from synthetic contaminated water (pp. 281-295) https://doi.org/10.5004/dwt.2021.26573
  31. Schultz et al. (2019) Stimulus-responsive antibiotic releasing systems for the treatment of wound infections 2(2) (pp. 704-716) https://doi.org/10.1021/acsabm.8b00577
  32. Tan et al. (2019) Thermoresponsive amphiphilic functionalization of thermally reduced graphene oxide to study graphene/bacteria hydrophobic interactions 35(13) (pp. 4736-4746) https://doi.org/10.1021/acs.langmuir.8b03660
  33. Jiang et al. (2021) Thermoresponsive nanostructures: from mechano-bactericidal action to bacteria release 13(51) (pp. 60865-60877) https://doi.org/10.1021/acsami.1c16487
  34. Bruk et al. (2020) Controlled release of ciprofloxacin and ceftriaxone from a single ototopical administration of antibiotic-loaded polymer microspheres and thermoresponsive gel 15(10) https://doi.org/10.1371/journal.pone.0240535
  35. Cao et al. (2019) Reversible thermoresponsive peptide–PNIPAM hydrogels for controlled drug delivery 20(9) (pp. 3601-3610) https://doi.org/10.1021/acs.biomac.9b01009
  36. Deirram et al. (2019) pH-responsive polymer nanoparticles for drug delivery 40(10) https://doi.org/10.1002/marc.201800917
  37. Tu et al. (2017) Functionalized graphene sheets for intracellular controlled release of therapeutic agents 9(47) (pp. 18931-18939) https://doi.org/10.1039/C7NR06588D
  38. Tu et al. (2017) Combination of surface charge and size controls the cellular uptake of functionalized graphene sheets 27(33) https://doi.org/10.1002/adfm.201701837
  39. Sattari et al. (2021) Functionalized graphene platforms for anticancer drug delivery https://doi.org/10.2147/IJN.S249712
  40. Nikfarjam et al. (2021) Antimicrobial ionic liquid-based materials for biomedical applications (Adv. Funct. Mater. 42/2021) 31(42) https://doi.org/10.1002/adfm.202170312
  41. Faghani et al. (2017) Controlled covalent functionalization of thermally reduced graphene oxide to generate defined bifunctional 2D nanomaterials 129(10) (pp. 2719-2723) https://doi.org/10.1002/ange.201612422
  42. Donskyi et al. (2021) Graphene sheets with defined dual functionalities for the strong SARS-CoV-2 interactions 17(11) https://doi.org/10.1002/smll.202007091
  43. Gholami et al. (2017) Functionalized graphene as extracellular matrix mimics: toward well-defined 2D nanomaterials for multivalent virus interactions 27(15) https://doi.org/10.1002/adfm.201606477
  44. Mohammadifar et al. (2021) Graphene-assisted synthesis of 2D polyglycerols as innovative platforms for multivalent virus interactions 31(22) https://doi.org/10.1002/adfm.202009003
  45. Lan et al. (2020) Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor 581(7807) (pp. 215-220) https://doi.org/10.1038/s41586-020-2180-5
  46. Clausen et al. (2020) SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2 183(4) (pp. 1043-1057) https://doi.org/10.1016/j.cell.2020.09.033
  47. Ahmadi et al. (2021) One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors 57(90) (pp. 11948-11951) https://doi.org/10.1039/D1CC04703E
  48. Zheng et al. (2021) 2D nanomaterials for tissue engineering and regenerative nanomedicines: recent advances and future challenges 10(7) https://doi.org/10.1002/adhm.202001743