TY - EJOUR
AU - Saleh, Mohanad Yakdhan
AU - Sadeek, Ghufran Th.
AU - Saied, Shakir Mahmood
PY - 2024
DA - January
TI - Preparation and characterization of a dual acidic Ionic Liquid functionalized Graphene Oxide nanosheets as a Heterogeneous Catalyst for the Synthesis of pyrimido[4,5-b] quinolines in water
T2 - Iranian Journal of Catalysis
VL - 13
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/preparation-and-characterization-of-a-dual-acidic-ionic-liquid-functionalized-graphene-oxide-nanosheets-as-a-heterogeneous-catalyst-for-the-synthesis-of-pyrimido45-b-quinolines-in-water/
DO - 10.30495/ijc.2023.1998276.2052
N2 - Pyrimido[4,5-b]quinolones play a significant role in medicinal chemistry owing to their various biological properties, including antihistaminic, antimalarial, antifungal, anticancer, antioxidant, antiviral, anti-microbial, and anti-inflammatory activities. A dual acidic ionic liquid anchored on graphene oxide nanosheets (GO-Si-Pr-Lysin-SO3H) was provided and characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR). The six-step process was utilized to create this catalyst, beginning with graphite powder. This catalyst was capable to develop the one-pot and three components (6-amino-1,3-dimethyluracil, dimedone, and different aromatic aldehydes) synthesis of pyrimido[4,5-b]quinolone derivatives at moderate temperature in water as a green medium (12 derivatives). The results obtained indicated that this method could be an effective approach for synthesizing pyrimido[4,5-b]quinolones with high yields ranging from 86% to 98% in a short reaction time of 15 to 40 minutes. In addition, the pointed catalyst shows reusability and recoverability without remarkable loss of catalytic activity.   Highlights GO-Si-Pr-Lysin-H-SO3H as an efficient heterogeneous catalyst and supported ionic liquid was provided. 12 types of pyrimido[4,5-b]quinolone derivatives using GO-Si-Pr-Lysin-SO3H were prepared. GO-Si-Pr-Lysin-H-SO3H show good catalytic activity for both electron-withdrawing and electron-donating substituents. GO-Si-Pr-Lysin-H-SO3H was characterized and identified using microscopic and spectroscopic techniques. GO-Si-Pr-Lysin-H-SO3H was reused for six catalytic cycle.  
IS - 4
PB - OICC Press
KW - 5-b]quinolones, Reusability., Ionic liquid, Graphene oxide, Green catalyst, Pyrimido[4 
EN -