TY - EJOUR
AU - Mokhtary, Masoud
PY - 2024
DA - February
TI - Green approach for the synthesis of pyranopyrazoles and hexahydroquinoline-3-carboxamides using unripe grape juice (verjuice) as catalyst
T2 - Iranian Journal of Catalysis
VL - 9
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/green-approach-for-the-synthesis-of-pyranopyrazoles-and-hexahydroquinoline-3-carboxamides-using-unripe-grape-juice-verjuice-as-catalyst/
N2 - Unripe grape juice (verjuice) as a natural catalyst was successfully applied to perform the one-pot reaction of aryl aldehydes, malononitrile, hydrazine hydrate and ethyl acetoacetate to synthesize pyranopyrazole derivatives in aqueous ethanol at room temperature in excellent yields. Furthermore, unripe grape juice catalyzed one-pot synthesis of hexahydroquinoline-3-carboxamide derivatives by the four-component reaction of arylaldehydes, dimedone, acetoacetanilide and ammonium acetate in high to excellent yield in ethanol at 70 ℃. The synthesized compounds were identified by FT-IR, 1H NMR and 13C NMR spectroscopic techniques and elemental analysis. An environmentally benign procedure, short reaction time, high yields and biocompatible natural catalyst are some advantages of this research.
IS - 1
PB - OICC Press
KW - Unripe grape juice, Hexahydroquinoline-3-carboxamides, Multi-component reactions, Pyranopyrazoles 
EN -