TY - EJOUR
AU - Safari, Javad
AU - Gandomi-Ravandi, Soheila
AU - Akbari, Zahra
PY - 2024
DA - February
TI - Improving methodology for the preparation of highly substituted imidazoles using nano-MgAl2O4 as catalyst under microwave irradiation
T2 - Iranian Journal of Catalysis
VL - 3
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/improving-methodology-for-the-preparation-of-highly-substituted-imidazoles-using-nano-mgal2o4-as-catalyst-under-microwave-irradiation/
N2 - An efficient synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles by one-step condensation of  an aldehyde, benzil, ammonium acetate and primary amine in the presence of nanocrystalline magnesium aluminate under microwave irradiation is described. The advantages of this catalyst are including simple work-up, low cost and reusability. Compared with conventional methods, the main advantages of the present procedure are its being a green method, its milder conditions, necessary shorter reaction time, and its higher yields and its selectivity. The structures of products were characterized by 1H NMR, 13C NMR, IR, elemental analyses, MS and UV spectral data. Their melting points were compared with literature report.
IS - 1
PB - OICC Press
KW - Solvent-free, Multi-component reaction, MW irradiation, Imidazoles, Nanocrystalline magnesium aluminate 
EN -