TY - EJOUR
AU - Azimi, Seyyedeh Cobra
PY - 2024
DA - February
TI - L-proline catalyzed synthesis of naphthopyranopyrimidines via multicomponent reaction
T2 - Iranian Journal of Catalysis
VL - 5
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/l-proline-catalyzed-synthesis-of-naphthopyranopyrimidines-via-multicomponent-reaction/
N2 - A green and efficient one pot, three component protocol for synthesis of naphthopyranopyrimidines by cyclocondensation of β-naphthol, aldehyde, and 6-amino-1,3-dimethyluracil using L-proline as a beneficial catalyst with high catalytic activity under solvent-free conditions at 100 °C is described. In this study, several types of aromatic aldehyde, containing electron-withdrawing groups as well as electron-donating groups, were rapidly converted to the corresponding naphthopyranopyrimidine derivatives in good to excellent yields. The present approach offers several advantages such as short reaction times, simple work-up, excellent yields, non-toxicity of the catalyst, and solvent-free conditions.To the best of our knowledge, this is the first report on the synthesis of naphthopyranopyrimidine derivatives using L-proline as a catalyst under solvent-free conditions. The catalysts can be recovered for the subsequent reactions and reused without any loss of efficiency.
IS - 1
PB - OICC Press
KW - 6-Amino-1, 3-dimethyluracil, Solvent-free, β-naphthol, L-proline 
EN -