TY - EJOUR
AU - Aboonajmi, Jasem
AU - Maghsoodlou, Malek Taher
AU - Hazeri, Nourallah
AU - Lashkari, Mojtaba
AU - Safarzaei, Mohyeddin
AU - Shirzaei, Moheb
PY - 2024
DA - February
TI - Multicomponent preparation of highly functionalized piperidines using FeCl3.6H2O as an efficient catalyst
T2 - Iranian Journal of Catalysis
VL - 5
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/multicomponent-preparation-of-highly-functionalized-piperidines-using-fecl3-6h2o-as-an-efficient-catalyst/
N2 - FeCl3.6H2O was used as an efficient catalyst for the synthesis of highly functionalized piperidines via a one-pot five-component reaction of aromatic amines, aromatic aldehydes and β-keto esters in EtOH at room temperature. The remarkable advantages offered by this method are good yields, simple procedure, short reaction times, no need to column chromatography and easy work-up. The structures of all compounds were characterized by comparison of their IR and NMR spectra with authentic samples. Also, the relative stereochemistry of these piperidines has been confirmed by single X-ray crystallography analysis in previously reported literature. Starting materials with electron-deficient or electron-releasing groups were reacted efficiently.
IS - 1
PB - OICC Press
KW - Aldehyde, Multicomponent, Functionalized piperidine, β-Keto ester 
EN -