TY - EJOUR
AU - Waghmare, Amit
AU - Patil, Tushar
AU - Kadam, Kailash
AU - Pandit, Shivaji Sandu
PY - 2024
DA - February
TI - SFHS: Reusable catalyst for the synthesis of polyhydroquinoline derivatives and its molecular docking studies against tyrosine protein kinase
T2 - Iranian Journal of Catalysis
VL - 5
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/sfhs-reusable-catalyst-for-the-synthesis-of-polyhydroquinoline-derivatives-and-its-molecular-docking-studies-against-tyrosine-protein-kinase/
N2 - An efficient synthesis of polyhydroquinoline derivatives is achieved via Hantzsch condensation reaction between aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of SFHS in ethanol. This method gives remarkable advantages such as shorter reaction time, simple workup procedure and good to excellent yields. Furthermore the catalyst can be recovered conveniently and reused efficiently. To analyze potential anticancer activity, synthesized derivatives were docked to tyrosine protein kinase (1YJ) against 4ST and PTR binding sites.
IS - 1
PB - OICC Press
KW - Multicomponent reaction, Polyhydroquinoline derivatives, Silica supported ferric hydrogen sulphate, Molecular docking 
EN -