TY - EJOUR
AU - Abbaspour, Sima
AU - Javanmardi, Parisa
PY - 2024
DA - February
TI - Phospho sulfonic acid: an efficient solid acid catalyst for the facile preparation of 1,4-dihydropyridines
T2 - Iranian Journal of Catalysis
VL - 5
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/phospho-sulfonic-acid-an-efficient-solid-acid-catalyst-for-the-facile-preparation-of-14-dihydropyridines/
N2 - A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforward and handling of the reagent is also easy. The attractive features of this protocol are: (i) The elimination of corrosive liquid acids; (ii) the use of an inexpensive and relatively non-toxic catalyst, and (iii) reusability of the catalyst.
IS - 2
PB - OICC Press
KW - Aldehyde, Multi-component reactions, PO(OSO3H)3, Hantzsch synthesis, Heterogeneous solid acid 
EN -