TY - EJOUR
AU - Bakherad, Mohammad
AU - Doosti, Rahele
AU - Mirzaee, Mahdi
AU - Jadidi, Khosrow
PY - 2024
DA - February
TI - Synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities
T2 - Iranian Journal of Catalysis
VL - 7
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/synthesis-of-pyrazolopyranopyrimidines-catalyzed-by-caffeine-supported-on-boehmite-nanoparticles-and-their-evaluation-for-anti-bacterial-activities/
N2 - The reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded BNPs-3-propyl-imidazolopyridinium hydrogen sulfate [BNPs-Caff]HSO4 as a new BNPs-supported ionic liquid (IL) catalyst. [BNPs-Caff]HSO4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl acetoacetate, barbituric acid, and an aldehyde. The attractive features of this method are simple procedure, clean reaction, use of a reusable catalyst, easy workup, and performing a multi-component reaction (MCR) in water. A number of synthesized compounds were screened for their in vitro anti-bacterial activities against the Gram-positive and Gram-negative bacteria using a well-diffusion method.
IS - 1
PB - OICC Press
KW - Anti-bacterial activity., Reusable catalyst., Boehmite nanoparticles, Caffeine, Pyrazolopyranopyrimidine 
EN -