@article{Adam_2024, title={Cascades Synthesis of N-Aryl Oxindole Nitrone Derivatives using Isatine Oximes and Arylboronic acids Catalyzed by Copper Acetate under Mild Conditions}, volume={14}, url={https://oiccpress.com/iranian-journal-of-catalysis/article/cascades-synthesis-of-n-aryl-oxindole-nitrone-derivatives-using-isatine-oximes-and-arylboronic-acids-catalyzed-by-copper-acetate-under-mild-conditions-2/}, DOI={10.57647/j.ijc.2024.1401.06}, abstractNote={Cu-catalysis was employed to create numerous (E)-5-bromo-N-aryl oxindole nitrones with satisfactory to excellent coupling efficiencies. This process involved the reaction of N-unprotected 5-bromoisatin-3-oximes and aryl-boronic acid derivatives under mild reactive conditions. Remarkably, the reaction exhibited tolerance towards several aryl-boronic acids containing diverse functional sensitivity subgroups (73% to 97% yields and 2 to 6 h). Extensive research has demonstrated that the (C=O) group present in 5-bromoisatin-3-oximes can serve as an inhibitory molecule or ligand, playing a crucial role in the generation of (E) oxindole nitrones. Highlights: In this research copper catalyzed cabon-nitrogen bond formatio 10 derivatives of N-aryl oxindole nitrone were prepared The starting materials were different aryl boronic acid and N-unprotected 5-bromoisatin-3-oximes\A reasonable mechanism was suggested }, number={1}, journal={Iranian Journal of Catalysis}, publisher={OICC Press}, author={Adam, Rita S.}, year={2024}, month={Mar.}, keywords={Nitrones, Cascade reaction, Catalyst, Synthesis, Isatin, Copper acetate} }