@article{Bakherad_Doosti_Mirzaee_Jadidi_2024, title={Synthesis of pyrazolopyranopyrimidines catalyzed by caffeine supported on boehmite nanoparticles and their evaluation for anti-bacterial activities}, volume={7}, url={https://oiccpress.com/iranian-journal-of-catalysis/article/synthesis-of-pyrazolopyranopyrimidines-catalyzed-by-caffeine-supported-on-boehmite-nanoparticles-and-their-evaluation-for-anti-bacterial-activities/}, abstractNote={The reaction of 3-chloropropyl boehmite nanoparticles with caffeine and sulfuric acid afforded BNPs-3-propyl-imidazolopyridinium hydrogen sulfate [BNPs-Caff]HSO4 as a new BNPs-supported ionic liquid (IL) catalyst. [BNPs-Caff]HSO4 proved to be an efficient heterogeneous catalyst for the synthesis of pyrazolopyranopyrimidines via a one-pot four-component reaction of hydrazine hydrate, ethyl acetoacetate, barbituric acid, and an aldehyde. The attractive features of this method are simple procedure, clean reaction, use of a reusable catalyst, easy workup, and performing a multi-component reaction (MCR) in water. A number of synthesized compounds were screened for their in vitro anti-bacterial activities against the Gram-positive and Gram-negative bacteria using a well-diffusion method.}, number={1}, journal={Iranian Journal of Catalysis}, publisher={OICC Press}, author={Bakherad, Mohammad and Doosti, Rahele and Mirzaee, Mahdi and Jadidi, Khosrow}, year={2024}, month={Feb.}, keywords={Reusable catalyst., Boehmite nanoparticles, Caffeine, Pyrazolopyranopyrimidine, Anti-bacterial activity.} }