TY - EJOUR
AU - Narkhede, Rahul
AU - More, Mahesh
AU - Patil, Swapnil
AU - Patil, Pravin
AU - Patil, Ashwini
AU - Deshmukh, Prashant
PY - 2024
DA - February
TI - Eco-friendly synthesis of surface grafted Carbon nanotubes from sugarcane cubes for development of prolonged release drug delivery platform
T2 - International Journal of Nano Dimension (Int. J. Nano Dimens.)
VL - 12
L1 - https://oiccpress.com/international-journal-of-nano-dimension/article/eco-friendly-synthesis-of-surface-grafted-carbon-nanotubes-from-sugarcane-cubes-for-development-of-prolonged-release-drug-delivery-platform/
DO - 10.22034/ijnd.2021.681077
N2 - Surface grafting of nanocarriers could modulate their properties and characteristics. As carbon nanotubes synthesis is a very tricky process and requires high-end methods, hence the present investigation was aimed to develop an eco-friendly method for synthesis carbon nanotubes (CNTs) and subsequent surface grafting for enhanced drug delivery application. The present study elaborates two-step chemical modifications; wherein the first step is catalytic cleavage of natural precursor in the presence of ferrocene and the second step involve chemical grafting of Acyclovir (ACV) as a model drug to understand the drug release behaviour. The catalytic cleavage of sugarcane cubes (natural precursor) was carried out in a closed copper tube, which prevents oxidation and results in a conversion of tubular nanostructures to amorphous carbon. The covalent attachment of ACV on purified CNTs (fCNTs) was done using carbodiimide chemistry. The preliminary Uv-Vis absorbance spectra defined at 260 nm was arised due to π-π* stacking of aromatic C-C bonds. The Fourier Transforms Infrared Spectroscopy (FTIR) indicated the hydroxyl stretch at 3300 cm-1 while amide I bond formation was observed at 1672 cm-1. The XRD spectra confirmed successful synthesis of CNTs. The calculated average crystallite size (Scherer equation) of synthesized CNTs was found to be 42.84 and 44.45 nm; it was also in accordance with the morphological observation as confirmed simultaneously using SEM analysis. The covalently attached ACV was released up to 80% during 8h of in vitro drug release study. The surface grafting potential of CNTs was found to be promising compared to other nanomaterials.
IS - 3
PB - OICC Press
KW - Carbodiimide Chemistry, Natural Precursor, Purification, Amorphous Carbon, Acyclovir 
EN -