TY - EJOUR
AU - Yadav, Pooja
AU - Singh, Priyanka
AU - Yadav, Monika
AU - Dangi, Kapil
AU - Kumar, Kapinder
AU - Verma, Anita Kamra
PY - 2024
DA - April
TI - Artificial intelligence for regular monitoring of diabetogenic wounds and exploring nanotherapeutics to combat the multifaceted pathophysiology
T2 - International Journal of Nano Dimension (Int. J. Nano Dimens.)
L1 - https://oiccpress.com/international-journal-of-nano-dimension/article/artificial-intelligence-for-regular-monitoring-of-diabetogenic-wounds-and-exploring-nanotherapeutics-to-combat-the-multifaceted-pathophysiology/
DO - 10.57647/j.ijnd.2024.1503.17
N2 - The multifaceted pathophysiology of diabetic wounds coupled with impaired diabetic wound healing remains a significant challenge for the medical community in the 21st century. Possibility of bacterial infections, insufficient vascular supply, increment in levels of oxidative stress, and abnormalities in defenses mechanism of antioxidant causes diabetic foot ulcers (DFU) that leads to significant morbidity. An effective treatment for diabetic wounds is still lacking. Chronic wounds are taking epidemic proportions, leading to an increased interest in exploring novel therapies to meet the challenges. Evaluating the progression in diabetic ulcers poses a major threat for the patients and clinician owing to logistics as irregular visits to the clinics. Unique properties of nanoparticles contain ultra-small size, increased surface-to-volume ratio, low cytotoxicity, enhanced cellular uptake, improved antibacterial activity, biocompatibility and biodegradability making their applications attractive against DFUs. Their potential for healing can be due to their superior antioxidant and anti-inflammatory activities. Further, nanoparticles are effective delivery vehicles for various small molecules, exosomes, metallic molecules, or conjugated with numerous biomaterials- chitosan (CS), hyaluronic acid (HA) and smart hydrogels (HG) to enhance their healing efficacy against diabetic wounds. This review focuses on the futuristic and potential viewpoints of nanoparticles for the therapeutics of diabetic wounds/DFUs. Artificial intelligence (AI) tools and optical sensors can further contribute effectively for the monitoring procedures. Software based on AI technology plays crucial role in assessment and provide continuous care throughout the treatment. AI also helps to connect healthcare experts with larger number of patients at the same time. Nanotherapeutics represents a promising innovative strategy for targeted treatment that can change the landscape of wound healing, by providing a physiologically stable micro-environment for the thorough wound-healing process.  
PB - OICC Press
KW - Diabetic/chronic wound, Optical sensors, Wound healing, Nanoparticles, DFUs 
EN -