TY - EJOUR
AU - Hosseini, Sepideh
AU - Hosseini, Somaye
PY - 2024
DA - February
TI - Impact of process parameters in the generation of nanoemulsions containing omega 3 fatty acids and α-tocopherol
T2 - International Journal of Nano Dimension (Int. J. Nano Dimens.)
VL - 8
L1 - https://oiccpress.com/international-journal-of-nano-dimension/article/impact-of-process-parameters-in-the-generation-of-nanoemulsions-containing-omega-3-fatty-acids-and-%ce%b1-tocopherol/
N2 - Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis results indicated that the variability of four responses could be depicted as a quadratic function of ultrasonic processing variables. This investigation revealed that, ultrasound cavitation is a powerful promising approach for controlled production of nanoemulsion with small average droplet size in a range of 94.5 ± 1.14 nm with a polydispersity index of 0.1 ± 0.022 with high α- tocopherol and linolenic acid content which are 851 ± 11.62 mg/L and 43 ± 1.27 mg/L, respectively. This study showed that applying appropriate time and intensity of low frequency ultrasound is considerable importance to maintain the nutritional value of nanoemulsions in bioactive delivery system. 
IS - 4
PB - OICC Press
KW - Droplet size, linolenic acid, Polydispersity index, Nanoemulsion, A-tocopherol 
EN -