@article{Mehrabifar_Riahi_2024, title={Pre-concentration of Penicillamine using Fe3O4NPS and analysis of it in drug formulations through spectroscopic method}, volume={9}, url={https://oiccpress.com/international-journal-of-nano-dimension/article/pre-concentration-of-penicillamine-using-fe3o4nps-and-analysis-of-it-in-drug-formulations-through-spectroscopic-method/}, abstractNote={First, an effective pre-concentration of penicillamine was done via Fe3O4NPS. Then, a simple, rapid and sensitive spectrophotometric method is described for the determination of penicillamine by 2, 6-dichlorophenolindophenol (2, 6-DCPIP), as the chromogenic agent in bulk drug and formulations. It produces a bluish green coloured compound with maximum absorbance 610 nm. Beer’s law was obeyed in the concentration range 0.005-0.100 ppm with molar absorptivity 1.97 × 103 L/mol/cm and RSD 0.3-0.82%. Statistical comparison of the results with those from the reference method reveals excellent agreement and accuracy and precision was ±0.481 to ±0.33%. This method is also applied on the whole blood and serum samples collected from the confirmed patients. The reaction of penicillamine with 2, 6-DCPIP was confirmed by FTIR and 1H NMR. The main advantage of 2, 6-DCPIP was its stability as a reagent solution, resulting in reliable and reproducible results.}, number={1}, journal={International Journal of Nano Dimension (Int. J. Nano Dimens.)}, publisher={OICC Press}, author={Mehrabifar, Atefeh and Riahi, Ahmad}, year={2024}, month={Feb.}, keywords={Fe3O4NPS, Magnetic Nanoparticle, Penicillamine, Spectrophotometry, Serum, 6-Dichlorophenolindophenol} }