TY - EJOUR
AU - Abedi, Mohammad Reza
PY - 2023
DA - November
TI - Quantitative Analysis of β-Blockers in Water Samples by HPLC Using Directly Suspended Droplet Microextraction
T2 - International Journal of Industrial Chemistry
VL - 14
L1 - https://oiccpress.com/international-journal-of-industrial-chemistry/article/quantitative-analysis-of-%ce%b2-blockers-in-water-samples-by-hplc-using-directly-suspended-droplet-microextraction/
DO - 10.57647/j.ijic.2023.1402.07
N2 - The aim of this study is using Directly Suspended Droplet Microextraction (DSDME) as the sensitive drug assays in environmental waters. This work explains the success of this liquid-phase microextraction technique used as sample pre-concentration technique. This attractive method, which is selective and enable substantial pre-concentration, has been used for determination of three β-blockers; Atenolol, Metoprolol and Propranolol as the model compounds. The effective parameters such as organic solvent, pH of donor and acceptor phases, phase volumes, extraction and back-extraction time, stirring rate and addition of salt are discussed. The extracted β-blockers were analyzed at room temperature by High Performance Liquid Chromatography (HPLC), equipped an Agilent Eclipse XDB-C18 column with particle size of 5μm (250mm×4.6 mm i.d.) and programmed wavelength fluorescence detector. The mobile phase was 0.01molL-1 NaH2PO4 (adjusted to pH 3.0 with phosphoric acid)-methanol-acetonitril (45:45:10, v:v:v). The flow rate was 1.0 mLmin-1. The separated β-blockers were detected using fluorometric detection. The results showed that practical pre-concentration factors varied from 34.8 to 171.6.
IS - 2
PB - OICC Press
KW - β-blockers, Directly Suspended Droplet Microextraction (DSDME), Fluorescence Detection, HPLC 
EN -