@article{Wang_Wang_Lv_Chen_Zhang_Yang_Ma_Guo_Zhang_2023, title={Influence of Zhigancao decoction on chronic heart failure combined with depression}, volume={13}, url={https://oiccpress.com/international-journal-of-industrial-chemistry/article/influence-of-zhigancao-decoction-on-chronic-heart-failure-combined-with-depression/}, abstractNote={Objective: To probe the impact of Zhigancao decoction on chronic heart failure (CHF) combined with Depression. Methods: A total of 122 CHF patients combined with Depression who were treated in our hospital treated from March 2020 to October 2022 were chosen for this research. The patients were separated into two groups using the different treatments: 60 cases in the control group (CG) received conventional Western medicine treatment, and 62 points in the observation group (OG) adopted Zhigancao decoction based on the CG. The total effective rate, TCM symptoms and signs scores, and levels of NT-proBNP, hs-CRP and MMP-9, LVEF, PHQ-9, SDS, and MLHF in both groups were compared. Results: After therapy, the total effective rate of patients in the OG was elevated relative to the CG (χ2=6.50, P<0.05), the scores of TCM symptoms together with signs in the OG were lower relative to the CG (P<0.05). NT-pro-BNP, hs-CRP together, with MMP-9 levels in the OG were lower relative to the CG (P<0.05), was no difference and discovered in LVEF between both groups (P>0.05), PHQ-9 together with SDS scores in the OG were reduced relative to the CG (P<0.05). MLHF scores in the OG were higher than the CG (P<0.05). Conclusion: Based on Western medicine therapy, Zhigancao decoction can relieve the clinical symptoms and observation indicators of CHF patients complicated with Depression, which is valuable for clinical Use.}, number={1}, journal={International Journal of Industrial Chemistry}, publisher={OICC Press}, author={Wang, Ying and Wang, Jun and Lv, Wang and Chen, Hu and Zhang, Yang and Yang, Qian and Ma, Xiaoli and Guo, Run and Zhang, Qianyu}, year={2023}, month={Nov.}, keywords={Chronic heart failure, Depression, Zhigancao decoction} }