OICC Press International Nano Letters 2228-5326 9 2 (June 2019) 2019 03 01 Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats 10.1007/s40089-018-0263-1 EN Kenneth Maduabuchi Ezealisiji Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, NG Xavier Siwe-Noundou Department of Chemistry, Rhodes University, Grahamstown, 6140, ZA Blessing Maduelosi Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, NG Nkemakolam Nwachukwu Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, NG Rui Werner Maçedo Krause Department of Chemistry, Rhodes University, Grahamstown, 6140, ZA Journal Article 2019 03 01 Abstract Current study reports a simple and one-pot synthesis of zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Solanum torvum and evaluation of its toxicological profile (0.5% w/w and 1.0% w/w) in Wistar albino rats with respect to the biochemical index. The nanoparticles were characterized using ultraviolet–visible spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction technique. Dynamic light scattering (DLS) and zeta potential of synthesized nanoparticles were analyzed to know the average size and stability of particles. Synthesized nanoparticles were stable, discreet, and mostly spherical, and size of particles was within the nanometre range. Biochemical markers of hepatic and renal functions were measured. Zinc oxide nanoparticles significantly decreased serum uric acid level ( p