OICC Press International Nano Letters 2228-5326 5 2 (June 2015) 2015 04 15 Efficient one-pot synthesis of pyrido[2,3-d]pyrimidines catalyzed by nanocrystalline MgO in water 10.1007/s40089-015-0145-8 EN Amaneh Mossafaii Rad Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, IR Masoud Mokhtary Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, IR Journal Article 2015 04 15 Abstract The direct three-component condensation of 6-aminouracil, 6-amino-2-thiouracil or 6-amino-1,3-dimethyluracil, with arylaldehydes and malononitrile to generate a series of pyrido[2,3- d ]pyrimidine derivatives has been carried out over nanocrystalline MgO with high efficiency in water as a green solvent at 80 °C. The morphology and structure of the nanocrystalline MgO were characterized by scanning electron microscopy, transmission electron microscopy and X-ray diffraction. The results confirmed the nanocrystalline MgO particle size is approximately 50 nm. This methodology offers significant improvements for the synthesis of pyrido[2,3- d ]pyrimidine derivatives with regard to the yield of products, simplicity in operation, and green aspects by avoiding toxic catalysts and solvents.