OICC Press International Nano Letters 2228-5326 11 3 (September 2021) 2021 04 24 Electrochemical sensing of dopamine via bio-assisted synthesized silver nanoparticles 10.1007/s40089-021-00339-9 EN Roomia Memon National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Ayaz Ali Memon National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Ayman Nafady Department of Chemistry, College of Science, King Saud University, Riyadh, 11451, SA Sirajuddin International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, PK Syed Tufail Hussain Sherazi National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Aamna Balouch National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Kanwal Memon National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Nazir Ahmed Brohi Institute of Microbiology, University of Sindh, Jamshoro, 76080, PK Aamna Najeeb National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, PK Journal Article 2021 04 24 Abstract A simple, environment-friendly, cost-effective procedure is proposed for the synthesis of silver nanoparticles (AgNPs) using aqueous leaf extract of Ziziphus mauritiana ( Zm L) as reducing as well as stabilizing agent and its application on glassy carbon electrode (GCE) for the detection of dopamine by cyclic voltammetry (CV). Results showed a substantial enhancement of peak current using Ag@GCE as compared to bare-GCE for the detection of neurotransmitter dopamine. The synthesized Zm L-AgNPs were characterized using ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infra-red (FT-IR) spectroscopy, X-ray diffraction (XRD) and atomic force microscopy (AFM). We investigated the electrochemical responses of both bare-GCE and Ag-assembled GCE using cyclic voltammetry to delineate the performance enhancement due to Zm L-AgNPs. The present Zm L-AgNP-assembled GCE displayed very high sensitivity and selectivity with excellent linear calibration range 10–100 µM for detection of dopamine with a limit of detection and limit of quantification values 0.1 and 0.3 µM, respectively. The sensor was successfully applied for dopamine detection in real urine samples.