OICC Press International Journal of Nano Dimension 2228-5059 8 3 2024 02 28 Voltammetric determination of amitriptyline based on graphite screen printed electrode modified with a Copper Oxide nanoparticles EN Hadi Beitollai Sciences, Graduate University of Advanced Technology, Kerman, Iran. Fariba Garkani Nejad Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran Somayeh Tajik NanoBioElectrochemistry Research Center, Bam University of Medical Sciences, Bam, Iran. Shohreh Jahani Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran Pourya Biparva Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran Journal Article 2024 02 28 A novel electrochemical sensor was proposed for the determination of amitriptyline based on the copper oxide (CuO) nanoparticles modified graphite screen-printed electrode. CuO nanoparticles were used to enhance the surface area of the electrode and then improve the sensitivity of the electrochemical sensor. Amitriptyline electrochemical response characteristics of the modified electrode in a phosphate buffer solution (PBS) of pH 7.0 were investigated by cyclic voltammetry, differential pulse voltammetry and chronoamperometry. The linear range for the detection of amitriptyline was changed from 1.0 µM to 200.0 μM with the detection limit of 0.4 μM (S/N=3). Finally, the proposed method was applied to measure amitriptyline in real samples. It was shown that the proposed sensor exhibited significant promise as a reliable technique for the detection of amitriptyline in real samples.