OICC Press International Journal of Nano Dimension 2228-5059 17 2 2026 04 10 Green synthesis of bis(indolyl)methane scaffolds as valuable biological materials catalyzed by Fe3O4/SiO2/PPA as a magnetic nanocatalyst 10.57647/ijnd-2026-1702-07 EN Fatemeh Chaltash Department of Chemistry, Am.c., Islamic Azad University, Amol, Iran Seyed Mohammad Vahdat Department of Chemistry, Am.c., Islamic Azad University, Amol, Iran https://orcid.org/0000-0001-7150-9128 Roberto Acevedo Universidad San Sebastián; Facultad de Ingeniería, Arquitectura y Diseño (FIAD); Bellavista 7. 8420524. Santiago. Chile Soheila Ghanbari Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, Tehran, Iran https://orcid.org/0009-0007-4756-8356 Mohammad Qandalee Department of Basic Sciences, Ga.C. Islamic Azad University, Garmsar, Iran Carlos J. Durán-Valle ACYS, Faculty of Sciences, Universidad de Extremadura, Badajoz, 06006, Spain Ignacio M. Lopez-Coca INTERRA, School of Technology, Universidad de Extremadura, Caceres, 10003, Spain https://orcid.org/0000-0001-9120-4495 Journal Article 2026 04 10 This study applied Fe3O4/SiO2/PPA magnetic nanocatalyst as a solid acid catalyst to produce bis(indolyl)methane derivatives (BIMs) under solvent-free conditions and at 50Oc. FTIR, XRD, EDX, FESEM, HRTEM, and BET were used for structure confirmation. The catalyst was environmentally friendly, heterogeneous, and recyclable without loss of catalytic activity. Also, this catalyst had high efficiency for the synthesis of bis(indolyl) methanes and the reaction products were obtained quickly. The synthesis of bis(indolyl)methanes from the reaction between indole derivatives and aldehydes has been carried out in short reaction times (5-30 min) with good to excellent yields (65-96%) using 50 mg of magnetic nanocatalyst at solvent-free conditions.