OICC Press International Journal of Nano Dimension 2228-5059 17 1 2026 01 02 Development of a Health Risk Management Framework in Workplaces Handling Nanomaterials Using Multi-Criteria Decision-Making Methods 10.57647/j.ijnd.2026.1701.08 EN Seyed Husein Naziri School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mostafa Pouyakian School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sedigheh Sadegh Hassani R & D manager of Sanat Afarin Mahan co., Tehran, Iran Pegah Safdari School of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran Somayeh Farhang Dehghan Environmental and Occupational Hazards Control Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran Journal Article 2026 01 02 This study developed a comprehensive framework for assessing and managing health risks of manufactured nanomaterials (MNM) in workplaces. The approach combined control banding with multi-criteria decision-making, informed by expert input and a literature review on MNM hazards. A three-layered risk assessment was applied: hazard banding using the Globally Harmonized System (GHS) for five toxic endpoints, exposure banding based on MNM physical state, manufacturing processes, and working conditions (yielding four bands), and integration via control banding to classify risk into five levels. These layers complement each other to enhance accuracy. Control measures were identified and evaluated using a General Technique for Evaluating Control Measures (GTECM), scoring effectiveness, cost, and feasibility, with acceptable inter-rater reliability. The framework was implemented as an online tool to support practical application in Iranian nanotechnology workplaces. Field testing in selected facilities demonstrated its usability and consistency. By systematically integrating hazard, exposure, and control data, the framework supports informed decision-making for occupational health and safety managers. It aims to strengthen risk management practices and promote safer handling of MNMs, contributing to improved workplace health in Iran’s growing nanotechnology sector.