OICC Press International Journal of Industrial Chemistry 2228-5547 17 1 2026 03 31 TiO₂ and Al₂O₃ - Water Nanofluids as Coolants in a Car Radiator 10.57647/ijic.2026.1701.01 EN Ahmad Esmaeeli Department of Chemical Engineering, Qu.c., Islamic Azad University, Quchan, Iran Mahmoudreza Khadangi Mahrood Department of Chemical Engineering, Qu.c., Islamic Azad University, Quchan, Iran Hossein Ghahremani Department of Chemical Engineering, Qu.c., Islamic Azad University, Quchan, Iran Journal Article 2026 03 31 In recent decades, extensive research has been conducted on the use of nanoparticles with high thermal conductivity in automotive cooling systems. In this study, the performance of a radiator cooling system using nanofluids containing TiO₂ and Al₂O₃, in comparison with distilled water as the coolant, was investigated experimentally and through neural network modeling. The experiments were performed using different concentrations of TiO₂ and Al₂O₃ nanofluids at various engine speeds. Our results showed that the Al₂O₃ and water nanofluid with a 0.1% concentration and the TiO₂ and water nanofluid with a 0.05% concentration can improve the cooling system performance by 50% and 25%, respectively, compared to pure deionized (DI) water. The data obtained in this experiment were analyzed using the GMDH neural network algorithm, and the model showed strong agreement with the experimental results, with deviations of only 6.8% and 8.2% for TiO₂ and Al₂O₃ nanoparticles, respectively. These findings demonstrate the significant potential of low-concentration TiO₂ and Al₂O₃ nanofluids to enhance automotive cooling efficiency, highlighting their applicability as promising alternatives to conventional coolant fluids.