OICC Press Iranian Journal of Catalysis 2345-4865 14 3 2024 07 01 Vitamin C as an efficient and green homogeneous catalyst for the synthesis of pyride[2,3-d:5,6-d′] dipyrimidine derivatives 10.57647/j.ijc.2024.1403.24 EN Morteza Yaghoobi Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran 0000-0001-8991-4498 Amir Karimipour-saryazdi Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 0000-0002-6028-8638 Mohammad Ali Ghasemzadeh Department of Chemistry, Qom Branch, Islamic Azad University, Qom, Iran 0000-0002-8309-6727 Journal Article 2024 07 01 In organic chemistry, one of the most important materials are heterocycle compounds. Among different heterocyclic compounds, the N-containing heterocyclic materials are very important owing to their numerous properties, which can be applied in different fields. In this work, we synthesized pyrido[2,3-d:5,6-d′] dipyrimidine derivatives over an efficient and green method. For this aim, we used vitamin C as a bio-based, green, and environmentally friendly catalyst for the synthesis of synthesis pyrido[2,3-d:5,6-d′] dipyrimidine derivatives through solvent-free conditions. The key advantages of our procedure are operational easiness, mild reaction conditions, high yields, and short reaction time, as well as green and eco-friendly catalysts. Research Highlights The first report for the synthesis of pyridopyrimidine derivatives by vitamin C. Pyridopyrimidines have significant properties including anti-bacterial, anti-oxidant, anti-cancer. The main advantages of the presented method are mild reaction conditions, high yields, and short reaction time. The products were characterized by FT-IR and 1H NMR spectroscopies. Vitamin C is introduces as a bio-based, green, and environmentally friendly catalyst.