OICC Press Iranian Journal of Catalysis 2345-4865 14 3 2024 08 31 Recent updates in the one-pot multicomponent synthesis of 3,4-disubstituted-isoxazole-5(4H)-ones and its activity: A review 10.57647/j.ijc.2024.1403.21 EN Avinash D. Aher Department of Chemistry MVP Samaj’s KRT Arts, BH Commerce and AM Science (KTHM) College, Nashik, Maharashtra, India 0000-0003-3742-0861 Dhiraj Kuthe Department of Applied Science and Humanities, School of Engineering and Sciences, MIT ADT University Pune, Maharashtra, India 0009-0004-0680-5173 Dnyaneshwar Ghodechor Department of Applied Science and Humanities, School of Engineering and Sciences, MIT ADT University Pune, Maharashtra, India 0009-0008-9468-2618 Manohar K. Jopale Department of Chemistry MVP Samaj’s KRT Arts, BH Commerce and AM Science (KTHM) College, Nashik, Maharashtra, India 0000-0001-5737-8537 Dnyaneshwar D. Lokhande Department of Chemistry MVP Samaj’s KRT Arts, BH Commerce and AM Science (KTHM) College, Nashik, Maharashtra, India 0000-0002-8178-3718 Amol H. Kategaonkar Department of Chemistry MVP Samaj’s KRT Arts, BH Commerce and AM Science (KTHM) College, Nashik, Maharashtra, India 0000-0002-4810-5894 Journal Article 2024 08 31 Isoxazole-5-(4H)-one derivatives have garnered considerable attention owing to their wide range of pharmacological activities, such as anti-inflammatory, analgesic, antimicrobial, and antitumor properties. The multicomponent synthesis of 3,4-disubstituted-isoxazole-5-(4H)-ones has attracted significant interest in recent years due to its effectiveness and capability to produce various molecular libraries. This review presents a thorough summary of the recent advancements in the synthetic methodologies utilized for the synthesis of these heterocyclic compounds. Emphasis is placed on the various catalytic systems, reaction conditions, reaction medium, and substrate scopes that have been explored to optimize yields and selectivity. Additionally, the review discusses the biological activities associated with 3,4-disubstituted-isoxazole-5-(4H)-ones, highlighting their potential as therapeutic agents. The integration of green chemistry principles and sustainable methodologies in these synthetic processes is also examined, reflecting the ongoing efforts to develop environmentally benign chemical processes. Through a critical analysis of recent literature, this review aims to provide a valuable resource for researchers in the field of heterocyclic chemistry and drug discovery, fostering further innovation and application of these versatile compounds. Research Highlights Isoxazole-5-(4H)-one derivatives have garnered considerable attention owing to their wide range of pharmacological activities. The multicomponent synthesis of 3,4-disubstituted-isoxazole-5-(4H)-ones has attracted significant interest in recent years due to its effectiveness and capability to produce various molecular libraries. This review presents a thorough summary of the recent advancements in the synthetic methodologies utilized for the synthesis of these heterocyclic compounds. Additionally, the review discusses the biological activities associated with 3,4-disubstituted-isoxazole-5-(4H)-ones, highlighting their potential as therapeutic agents. Through a critical analysis of recent literature, this review aims to provide a valuable resource for researchers in the field of heterocyclic chemistry and drug discovery, fostering further innovation and application of these versatile compounds.