OICC Press Iranian Journal of Catalysis 2345-4865 8 3 2024 02 03 Silica-anchored Cu(I) aminothiophenol complex: An efficient heterogeneous catalyst for synthesis of 1,4-disubstituted 1,2,3-triazoles in water EN Mohammad Bakherad Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Ali Keivanloo Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Amir Hossein Amin Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Pooya Ghmari Faculty of Chemistry, Shahrood University of Technology, Shahrood, Iran. Journal Article 2024 02 03 An efficient method has been developed for synthesis of 1,4-disubstituted 1,2,3-triazoles using the silica-anchored Cu(I) aminothiophenol complex [SiO2-AT-Cu(I)] as a novel heterogeneous catalyst. The prepared catalyst is characterized by the FT-IR spectroscopy, and TGA, SEM, and ICP techniques. Terminal alkynes react with aroyl bromides and sodium azide in the presence of CuI anchored on silica in water at 80°C. The reactions exclusively generate the corresponding regiospecific 1,4-disubstituted 1,2,3-triazoles in good yields. The attractive features of this method are the simple procedure, clean reaction, use of a reusable catalyst, easy workup, and performing a click reaction in water. Moreover, the catalyst can be removed from the reaction mixture by means of simple filtration, and used again for up to five runs without a remarkable loss in its activity.