OICC Press Iranian Journal of Catalysis 2345-4865 7 4 2024 02 03 Baker’s yeast catalyzed Henry reaction: Biocatalytic C-C bond formation EN Prabhakar Shrivas Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440 010, India Nitesh Punyapreddiwar Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440 010, India Atul Wankhade Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440 010, India Sangesh Zodape Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440 010, India Umesh Pratap Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, 440 010, India Journal Article 2024 02 03 The C-C bond formation is an important reaction in organic synthesis to obtain value-added intermediates. Therefore, in this paper an attempt has been made to accelerate the Henry reaction (C-C bond formation) between aryl aldehydes and nitromethane using less expensive whole cell biocatalyst, baker’s yeast (BY). The scope of the methodology was also tested for the heteryl aldehyde i.e. 2-chloro-3-formyl quinoline to obtain the corresponding quinoline containing nitroalcohol. The developed protocol is highly efficient and completely environmentally friendly. The work addressed the issue of non-aqueous biocatalysis, since Henry reaction catalysed by baker's yeast has been carried out in ethanol.