OICC Press Iranian Journal of Catalysis 2345-4865 6 5 2024 02 03 Synthesis of 4-(trifluoromethyl) coumarins using nano sulfated-titania as solid acid catalyst under solvent-free conditions EN Mona Hosseini-Sarvari Department of Chemistry, Shiraz University, Shiraz 71454, I.R. Iran. Sepideh Najafvand-Derikvandi Department of Chemistry, Shiraz University, Shiraz 71454, I.R. Iran. Journal Article 2024 02 03 Nano sulfated titania was tested as solid acid heterogeneous catalyst for the synthesis of 4-(Trifluoromethyl) coumarin and coumarin derivatives under solvent-free condition. Factorial design evidenced a positive effect of reaction temperature, amount of catalyst, and solvents.  This nano-sized sulfated titania has been prepared by a sol-gel hydrothermal process. The prepared sulfated titania showed high catalytic activity in the synthesis of 4-(Trifluoromethyl) coumarin and coumarin derivatives. This method is of great value because of its environmentally benign character, easy handling, high yields, convenient operation, and green. FT-IR studies show that the catalyst can be reused for acylation without loss of catalytic activity.