OICC Press Iranian Journal of Catalysis 2345-4865 6 4 2024 02 03 An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water EN Mahshid Hossaini Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran. Reza Heydari Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran. Malek Taher Maghsoodlou Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran Journal Article 2024 02 03 In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, 1HNMR, 13CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.