OICC Press Iranian Journal of Catalysis 2345-4865 6 3 2024 02 03 One-pot synthesis of tri- and tetrasubstituted imidazoles using nano-LaMnO3 perovskite-type oxide as reusable heterogeneous catalyst in solvent-free condition EN Haleh Sanaeishoar Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Haman Tavakkoli Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Mahsa Asareh Department of Chemistry, Dezful Branch, Islamic Azad University, Dezful, Iran. Fouad Mohave Young Researchers and Elite Club, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Journal Article 2024 02 03 A convenient synthetic method for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetra substituted imidazole derivatives, has been developed via one-pot condensation reaction in solvent-free condition when aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted using 0.8 mol% of NP-LaMnO3 at 80 °C under solvent free conditions. Catalyst could be recovered and reused in five reaction cycles without any loss of its activities, giving a total turnover number (TON) = 594 and turn over frequency (TOF) = 71 h−1. High yield, little catalyst loading, elimination of solvent, simple workup, recovery and reusability of the catalyst are some of the impressive features of the present method.