OICC Press Iranian Journal of Catalysis 2345-4865 6 3 2024 02 03 CdO nanoparticles as an efficient, mild and recyclable catalyst for the synthesis of 2-aryl benzoxazole derivatives by grinding method EN Ashok V. Borhade Department of Chemistry, Research Center, HPT Arts and RYK Science College, Nasik, 422005, India. Bhagwat K. Uphade bDepartment of Chemistry, Research Center, Padmashri Vikhe Patil College, Pravaranagar, 413713, India. Journal Article 2024 02 03 CdO nanoparticles efficiently catalyzes the condensation of aromatic aldehydes with 2-aminophenol at room temperature to afford 2-aryl benzoxazole derivatives by grinding method. The reactions proceed under heterogeneous and mild conditions to provide 2-aryl benzoxazoles in excellent yields (87-97 %) with high purity under solvent free condition. The reaction requires short time (5-23 minutes) under moderate conditions. The purification of products by non-chromatographic methods is additional feature of this method. A series of 2-aryl bezoxazole have been successfully synthesized by this method. Ease of recycled catalyst, cleaner process, solvent free and lower catalytic loading are the most advantages of the proposed method.