OICC Press Iranian Journal of Catalysis 2345-4865 5 2 2024 02 03 Phospho sulfonic acid: an efficient solid acid catalyst for the facile preparation of 1,4-dihydropyridines EN Sima Abbaspour Department of Chemistry, Faculty of science, Islamic Azad University, Rasht Branch, Rasht, Iran. 0000-0001-8940-2927 Parisa Javanmardi Chemistry Department, Qaemshahr Branch, Islamic Azad University, Qaemshahr, I. R. Iran Journal Article 2024 02 03 A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforward and handling of the reagent is also easy. The attractive features of this protocol are: (i) The elimination of corrosive liquid acids; (ii) the use of an inexpensive and relatively non-toxic catalyst, and (iii) reusability of the catalyst.