OICC Press Iranian Journal of Catalysis 2345-4865 5 2 2024 02 03 Highly efficient multicomponent Biginelli’s synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by Al-MCM-41 under solvent-free conditions EN Soheil Sayyahi Department of Chemistry, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran. Mehdi Behvandi Behvandi Department of Chemistry, College of Chemical Engineering, Mahshahr Branch, Islamic Azad University, Mahshahr, Iran. Journal Article 2024 02 03 In this study, an efficient and green process for the synthesis of dihydropyrimidin-2(1H)-ones from aromatic benzaldehydes, ethyl acetoacetate and urea using Al-MCM-41 as heterogeneous catalyst and microreactor under solvent-free conditions has been developed. The advantages of this method are easy work-up procedure, regeneration of the catalyst, clean and neutral reaction conditions.