OICC Press Iranian Journal of Catalysis 2345-4865 13 3 2023 09 02 La2O3 as a very effective double‌-functional catalyst for the production of 2-amino-4-aryl-4H-pyrans and Pyrazolopyranopyrimidines 10.30495/ijc.2023.1990117.2017 EN Alireza Kohzadian Department of Chemistry, Faculty of Sciences, Ilam Branch, Technical and Vocational University (TVU), Ilam, Iran 0000-0001-9498-9822 Rohollah Fathollahi Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Iran Mostafa Karami Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Iran Esmail Korani Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran Abdolkarim Zare Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran 0000-0002-8210-3155 Journal Article 2023 09 02 Lanthanum (III) oxide (La2O3) was applied as an efficient bifunctional catalyst to develop a new methodology in the production of 2-amino-4-aryl-4H-pyrans and pyrazolopyranopyrimidines in the absence of solvent. In both synthetic protocol, due to the dual functionality of lanthanum­ (III) oxide (i.e. having basic and acidic Lewis sites), it was very useful and general, and plausible mechanisms were presented in support of this generality and high capability. The current protocol featured environmentally friendly conditions, the ability to recycle and reuse the heterogeneous catalyst up to 6 times, providing products in short times with high yields, easy work-up and no need for difficult steps of catalyst synthesis by using a commercially available catalyst, which makes it an appealing route for the preparation of these derivatives.