OICC Press Iranian Journal of Catalysis 2345-4865 12 4 2023 12 22 Synthesis of 1,3-diphenyl-2-propyn-1-ol derivatives in water catalyzed by silver ions immobilized on the magnetic cross-linked chitosan 10.30495/ijc.2022.1964242.1954 EN Fatemeh Rafiee Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Tehran, Iran Sahar Kermani Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Tehran, Iran Journal Article 2023 12 22 In this work, chitosan biopolymer was cross-linked by starch oxide through the covalent bond formation between amine groups of chitosan and aldehyde functional of oxidized starch. A magnetic bio-support was obtained due to the treatment of the produced hybrid biopolymer with iron oxide nanoparticles. As a result of exposing of silver nitrate salt to magnetic polymer, silver ions (Ag2O) and also Ag metal nanoparticles were deposited on this bio-support. The silver oxide was decorated on the magnetic chitosan biopolymer could catalyzed the cross-coupling reaction of substituted benzaldehydes with phenylacetylene in the presence of PPh3 (20 mol%) in water to achieve 1,3-diphenyl-2-propyn-1-ol derivatives in good yields at proper reaction times. Highlights The magnetic chitosan was modified with starch oxide as a stable biosupport for Ag immobolization. The nanocatalyst was showed high activity in the synthesis of 1,3-diphenyl-2-propyn-1-ol derivatives in water. The nanocatalyst was reused for several cycles without significant difference in activity.