OICC Press Iranian Journal of Catalysis 2345-4865 11 1 2024 01 19 Synthesis and Characterization of Fe3O4@APTES@MOF-199 Magnetic Nanocatalyst and Its Application in the Synthesis of Quinoxaline Derivatives EN Sami Sajjadifar Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran 0000-0001-8661-1264 Issa Amini Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran Mina Karimian Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran Journal Article 2024 01 19 In this research, design and synthesis of Fe3O4@APTES@MOF-199magnetic nanocatalyst nanoparticles as a novel, recyclable and heterogeneous catalyst was developed. The magnetic nanocatalyst was analyzed using various spectroscopic methods such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), powder X-ray diffraction (XRD), energy dispersive X‐ray (EDX), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM). The particle size of the nanocatalyst is about 15-96 nm. In addition, magnetic nanocatalysts have been successfully applied to the synthesis of quinoxaline derivatives with a range of derivatives. The crude compounds were isolated in 84-97% yields. The recyclability of the catalyst was evaluated up to 5 times, with no loss in catalysis activity.