OICC Press Iranian Journal of Catalysis 2345-4865 2026 2026 08 08 Fabrication of the Most Efficient ZIF-8 Nanocomposite Modified Electrode for Specific Biosensing of Non-steroidal Anti-inflammatory Drug 10.57647/ijc.2026.1603.20 EN Farqad A. Albaidhani Department of Engineering, College of Engineering, Prosthetics and Orthotics University of Kerbala, Karbala, Iraq Zena Abdul-Ameer Mahdi Department of Medical physics, College of Applied Medical Sciences, University of Kerbala, Karbala, Iraq Hajar Altemeemi Department of Biochemistry, College of medicine, University of Kerbala, Karbala, Iraq Hasan Zandi Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran Ali Ehsani Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran Seyed Mohammad Hossein Tabatabaei Department of Chemistry, Faculty of Science, University of Qom, Qom, Iran Journal Article 2026 08 08 In this research, metal-organic frameworks (MOFs) with notable adsorption capacity and catalytic efficiency were utilized to construct electrochemical sensors for the quantification of mefenamic acid in aqueous environments. A zeolitic imidazolate framework (ZIF-8) was prepared and integrated with copper oxide sheets to modify a GCE, resulting in a novel sensing platform for mefenamic acid detection. The constructed ZIF-8 composites were systematically characterized through conventional surface analyses. Electrochemical evaluation of the prepared electrode, performed using conventional electrochemical techniques (CV, CA, and EIS), confirmed its effectiveness in determining mefenamic acid concentrations. Under optimized experimental conditions, square wave voltammetry (SWV) revealed a linear response within the 0.02-80 µmol L-1 range, with a LOD of 1.5× 10-3 µmol L-1. Furthermore, the fabricated sensor was successfully applied to real sample analysis of MFA, achieving recovery values between 97.2% and 103.0%. Highlights ·       Developing a simple and facile process for synthesis MOF nanocomposite ·       Presenting a novel and efficient nanocomposite materials for electrochemical oxidation of MFA. ·       Presented nanocomposite electrode shows a higher catalytic performance for oxidation of MFA. ·       Effective detection of MFA in real samples (medication, serum, and urine).