OICC Press Iranian Journal of Catalysis 2345-4865 15 2 2025 05 28 Fabrication of nano-[Fe3O4@SiO2@Si-Pr-Bipyr][FeCl4] as a novel magnetic nanocatalyst, and its utility for the construction of 1,2,4-triazolo[1,5-a]pyrimidines 10.57647/j.ijc.2025.1502.21 EN Abdolkarim Zare Department of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, Iran https://orcid.org/0000-0002-8210-3155 Elham Jazinizadeh Department of Chemistry, Payame Noor University, Tehran, Iran Fatemeh Mostaghar Department of Chemistry, Payame Noor University, Tehran, Iran Habibeh Golchaman Department of Chemistry, Payame Noor University, Tehran, Iran Seyed Sajad Sajadikhah Department of Chemistry, Payame Noor University, Tehran, Iran Marziyeh Barzegar Department of Chemistry, Payame Noor University, Tehran, Iran Journal Article 2025 05 28 Nano-[Fe3O4@SiO2@Si-Pr-Bipyr][FeCl4] (NFSPBF), as a novel magnetic nanomaterial, was fabricated, and its structure was corroborated using EDX, elemental mapping, FE-SEM, XRD, FT-IR, TG, and VSM analyses. In continuation, NFSPBF was employed as an efficacious catalyst for the one-pot multi-component reaction of acetoacetanilide, aryl aldehydes, and 3-amino-1,2,4-triazole to give 1,2,4-triazolo[1,5-a]pyrimidines in high yields (86-95%) and short times (10-15 min). NFSPBF could act as a dual-functional catalyst; FeCl4− of nano-[Fe3O4@SiO2@Si-Pr-Bipyr][FeCl4] is a Lewis acid, and its pyridine moiety is a base. It was reusable for two times without a remarkable decrement in its catalytic performance. Research Highlights Fabrication of nano-[Fe3O4@SiO2@Si-Pr-Bipyr][FeCl4] as a novel magnetic nanocatalyst was introduced. Full characterization of the nanocatalyst was performed. Utility of the catalyst for the construction of 1,2,4-triazolo[1,5-a]pyrimidines was checked. Constructing 1,2,4-triazolo[1,5-a]pyrimidines in high yields and short times were obtained. Proposing a mechanism based on dual-functionality of the catalyst was provided.