10.57647/ijc.2026.1602.16

Synthesis of Magnetic Mesoporous Fe3O4@SB Nanocomposite Adsorbent for Efficient Removal of Pharmaceutical Active Compounds from Water Solution

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Supplementary Information
  • Somayyeh Shenavaie asl1,
  • Afshin Pourahmad*1,
  • Somayyeh Rostamzadeh Mansour2,
  • Nastaran Sohrabi-Gilani2,
  1. Department of Chemistry, Ra. C., Islamic Azad University, Rasht, Iran
  2. Department of Chemistry, Ard. C., Islamic Azad University, Ardebil, Iran

Received: 2025-11-24

Revised: 2026-01-06

Accepted: 2026-02-08

Published Online: 2026-05-08

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Shenavaie asl, S., Pourahmad, A., Rostamzadeh Mansour, S., & Sohrabi-Gilani, N. (2026). Synthesis of Magnetic Mesoporous Fe3O4@SB Nanocomposite Adsorbent for Efficient Removal of Pharmaceutical Active Compounds from Water Solution. Iranian Journal of Catalysis, 2026. https://doi.org/10.57647/ijc.2026.1602.16
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Abstract

This study reports the successful synthesis of a novel magnetic nanocomposite, Fe3O4@SB, for the efficient removal of pharmaceutical active compounds (PhACs) from water. The material was fabricated by grafting a robust, mesoporous Schiff base (SB) network onto superparamagnetic Fe3O4 nanoparticles. The adsorption performance was evaluated for three model pharmaceuticals: 5-fluorouracil, mefenamic acid, and tryptophan. Under optimized conditions, the Fe3O4@SB nanocomposite exhibited exceptional removal efficiencies exceeding 96% for all compounds, with remarkably rapid kinetics reaching equilibrium within 10–15 min. Adsorption isotherm analysis revealed that the process followed the Langmuir model, indicating monolayer adsorption, with high maximum capacities for PhACs. Furthermore, the nanocomposite demonstrated excellent reusability over five consecutive adsorption-desorption cycles with minimal loss in capacity. The combination of high efficiency, rapid kinetics, facile magnetic separation, and robust stability positions Fe3O4@SB as a highly promising and practical adsorbent for the remediation of pharmaceutical-contaminated water.

Research highlights:

·       Synthesis of a novel Fe3O4@SB nanocomposite.

·       Exceptional and rapid adsorption performance for pharmaceutical compounds.

·       High adsorption capacities and favourable reusability.

·       Superparamagnetic property for instantaneous separation.

·       Simultaneous removal of three different pharmaceuticals.

Keywords

  • Adsorption; Fe3O4; Magnetic nanocomposite; Pharmaceutical active compounds (Phuc's); Schiff base; Water treatment
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Supplementary Information

References

  1. C.F. Couto, L.C. Lange, M.C. Amaral, J. Water Process Eng. 32 (2019) 100927. https://doi.org/10.1016/j.jwpe.2019.100927.
  2. M.A. Vaudreuil, S.V. Duy, G. Munoz, S. Sauvé, Sci. Total Environ. 846 (2022) 157353. https://doi.org/10.1016/j.scitotenv.2022.157353.
  3. A. Majumder, B. Gupta, A.K. Gupta, Environ. Res. 176 (2019) 108542. https://doi.org/10.1016/j.envres.2019.108542.
  4. B.A. Otoo, I.A. Amoabeng, G. Darko, L.S. Borquaye, Toxicol. Rep. 9 (2022) 1491–1500. https://doi.org/10.1016/j.toxrep.2022.07.003.
  5. L.O. Omuferen, B. Maseko, J.O. Olowoyo, Environ. Monit. Assess. 194 (2022) 306. https://doi.org/10.1007/s10661-022-09846-4.
  6. M. Jalilian, P. Parvizi, M.R. Zangeneh, Water Environ. Res. 97 (2025) e70062. https://doi.org/10.1002/wer.70062.
  7. M.D. Nguyen, H.V. Tran, S. Xu, T.R. Lee, Appl. Sci. 11 (2021) 11301. https://doi.org/10.3390/app112311301.
  8. V. Singh, Corros. Manag. 34 (2024) 141–162. https://doi.org/10.3390/4asxce56.
  9. R. Shekhanavar, S. Khatavi, B.G. Hegde, K. Kantharaju, Iran. J. Catal. 15 (2025). https://doi.org/10.57647/j.ijc.2025.1502.17.
  10. N. Zekri, R. Fareghi-Alamdari, Iran. J. Catal. 14 (2024). https://doi.org/10.57647/j.ijc.2024.1401.02.
  11. S.P. Schwaminger, C. Syhr, S. Berensmeier, Crystals 10 (2020) 214. https://doi.org/10.3390/cryst10030214.
  12. A.P. Côté, A.I. Benin, N.W. Ockwig, M. O'Keeffe, A.J. Matzger, O.M. Yaghi, Science 310 (2005) 1166–1170. https://doi.org/10.1126/science.1120411.
  13. Y. Ma, X. Kuang, X. Deng, B. Zi, J. Zeng, J. Zhang, Z. Zhu, Y. Zhang, Q. Liu, Microporous Mesoporous Mater. 335 (2022) 111701. https://doi.org/10.1016/j.micromeso.2022.111701.
  14. J.L. Segura, M.J. Mancheño, F. Zamora, Chem. Soc. Rev. 45 (2016) 5635–5671. https://doi.org/10.1039/C5CS00878F.
  15. G. Lin, C. Gao, Q. Zheng, Z. Lei, H. Geng, Z. Lin, H. Yang, Z. Cai, Chem. Commun. 53 (2017) 3649–3652. https://doi.org/10.1039/C7CC00482F.
  16. M. Moharramnejad, T. Sayah, Z. Ghehsareh, M.M. Rezaei, A.H. Amini, R.E. Malekshah, M. Shahi, B. Mirtamizdoust, A. Ehsani, J. Haribabu, S.C. Hsu, J. Drug Delivery Sci. Technol. 102 (2024) 106320. https://doi.org/10.1016/j.jddst.2024.106320.
  17. L. You, K. Xu, G. Ding, X. Shi, J. Li, S. Wang, J. Wang, J. Mol. Liq. 320 (2020) 114456. https://doi.org/10.1016/j.molliq.2020.114456.
  18. J. Wang, Q. Huang, W. Guo, D. Guo, Z. Han, D. Nie, Toxins 15 (2023) 117. https://doi.org/10.3390/toxins15020117.
  19. H. Zhang, W. Ma, C. Qiang, J. Nie, L. Ma, Y. Zhang, K. Wang, RSC Adv. 15 (2025) 8111–8120. https://doi.org/10.1039/D5RA00811E.
  20. D. Kirubakaran, J.B. Wahid, N. Karmegam, R. Jeevika, L. Sellapillai, M. Rajkumar, K.J. SenthilKumar, Biomed. Mater. Devices (2025) 1–26. https://doi.org/10.1007/s44174-025-00295-4.
  21. S.I.A.R. Shah, W. Ahmad, M. Anwar, R. Shah, J.A. Khan, N.S. Shah, A. Al-Anazi, C. Han, Appl. Catal. O Open (2025) 207049. https://doi.org/10.1016/j.apcato.2025.207049.
  22. W. Wu et al., Adv. Mater. Interfaces 9 (2022) 2201423. https://doi.org/10.1002/admi.202201423.
  23. N. Omrani, A. Nezamzadeh-Ejhieh, M. Alizadeh, Desalin. Water Treat. 162 (2019) 290–302. https://doi.org/10.5004/dwt.2019.24352.
  24. L. You, K. Xu, G. Ding, X. Shi, J. Li, S. Wang, J. Wang, J. Mol. Liq. 320 (2020) 114456. https://doi.org/10.1016/j.molliq.2020.114456.
  25. M. Al-Kelani, N. Buthelezi, Skin Res. Technol. 30 (2024) e13733. https://doi.org/10.1111/srt.13733.
  26. W. Wu, Z. Wu, T. Yu, C. Jiang, W.S. Kim, Sci. Technol. Adv. Mater. 24 (2023) 2153431. https://doi.org/10.1088/1468-6996/16/2/023501.
  27. S.R. Ansari, J. Mahajan, A. Teleki, WIREs Nanomed. Nanobiotechnol. 16 (2024) e1963. https://doi.org/10.1002/wnan.1963.
  28. J.E. Ogbezode, U.S. Ezealigo, A. Bello, V.C. Anye, A.P. Onwualu, Discover Nano 18 (2023) 125. https://doi.org/10.1186/s11671-023-03898-2.
  29. S.G. Hasan, A.V. Gupta, B.V. Reddi, Mater. Today Proc. 47 (2021) 4137–4141. https://doi.org/10.1016/j.matpr.2021.08.146.
  30. H. Quanguo, Z. Lei, W. Wei, H. Rong, H. Jingke, Sens. Mater. 22 (2010) 285–295. https://doi.org/10.18494/SAM.2010.622.
  31. M.S. Sharif, H. Hameed, A. Waheed, M. Tariq, A. Afreen, A. Kamal, E.A. Mahmoud, H.O. Elansary, S. Saqib, W. Zaman, Molecules 28 (2023) 3403. https://doi.org/10.3390/molecules28083403.
  32. S. Bassim, A.K. Mageed, A.A. AbdulRazak, H.S. Majdi, Inorganics 10 (2022) 260. https://doi.org/10.3390/inorganics10120260.
  33. B. Mashhourzad, B. Zeynizadeh, Nanoscale Adv. (2025). https://doi.org/10.1039/D4NA01020E.
  34. J. Villarroel-Rocha, D. Barrera, K. Sapag, Microporous Mesoporous Mater. 200 (2014) 68–78. https://doi.org/10.1016/j.micromeso.2014.08.017.
  35. S. Sani, R. Adnan, W.D. Oh, A. Iqbal, Nanomaterials 11 (2021) 2742. https://doi.org/10.3390/nano11102742.
  36. J. Tom, Last accessed March 3, 2021 (2022) [Incomplete source].
  37. M. Liu, Appl. Comput. Eng. 159 (2025) 85–92. https://www.ewadirect.com/proceedings/ace/article/view/23761.
  38. V. Dharmawan, I. Rahmawati, A.R. Sanjaya, B.E. Dewi, E. Saepudin, T.A. Ivandini, Int. J. Technol. 16 (2025) 672–685. https://doi.org/10.14716/ijtech.v16i2.7176.
  39. Q. Wang, G. Wang, S. Xie, X. Zhao, Y. Zhang, Exp. Ther. Med. 17 (2019) 2694–2702. https://doi.org/10.3892/etm.2019.7238.
  40. S. Abolghasemi, A.R. Nasiri, M. Hashemi, S. Rajabi, F. Rahimi, Appl. Water Sci. 15 (2025) 1–54. https://doi.org/10.1007/s13201-025-02360-1.
  41. M. Sun, X. Bai, X. Fu, X. Yu, Z. Ye, M. Zhang, Y. Qiu, Sci. Rep. 15 (2025) 4751. https://doi.org/10.1038/s41598-025-87901-z.
  42. A.A. Siyal, R.M. Mohamed, F. Ahmad, M.A. Malek, M. Alsubih, R. Shamsuddin, S. Hussain, S. Musa, RSC Adv. 15 (2025) 17843–17861. https://doi.org/10.1039/D5RA02007G.
  43. S. Siratham, K. Osathaphan, P. Punyapalakul, Sci. Rep. 15 (2025) 34454. https://doi.org/10.1038/s41598-025-17629-3.
  44. L.Y. George, L. Ma, W. Zhang, G. Yao, Environ. Sci. Eur. 35 (2023) 21. https://doi.org/10.1186/s12302-023-00725-4.
  45. R. Öztekin, D.T. Sponza, Clin. Trials Clin. Res. 3 (2024). https://doi.org/10.31579/2834-5126/068.
  46. S.K. Pereira, S. Kini, B. Prabhu, G.P. Jeppu, Appl. Water Sci. 13 (2023) 29. https://doi.org/10.1007/s13201-022-01800-6.
  47. A. Gençer, B.U. Karataş, Ö. Topel, N. Kiraz, Turk. J. Chem. 48 (2024) 50–64. https://doi.org/10.55730/1300-0527.3638.
  48. A.M. Alkafajy, T.M. Albayati, Mater. Today Commun. 23 (2020) 100890. https://doi.org/10.1016/j.mtcomm.2019.100890.
  49. S.H. Yu, Y. Wang, Y.Y. Wan, J.K. Guo, Environ. Sci. Pollut. Res. 30 (2023) 94401–94413. https://doi.org/10.1007/s11356-023-29060-0.
  50. A.J. Jafari, B. Kakavandi, R.R. Kalantary, H. Gharibi, A. Asadi, A. Azari, A.A. Babaei, A. Takdastan, Korean J. Chem. Eng. 33 (2016) 2878–2890. https://doi.org/10.1007/s11814-016-0155-x.
  51. O. Reyes-Vallejo, R.M. Sánchez-Albores, J. Escorcia-García, A. Cruz-Salomón, P. Bartolo-Pérez, A. Adhikari, M. del Carmen Hernández-Cruz, H.H. Torres-Ventura, H.A. Esquinca-Avilés, Environ. Sci. Pollut. Res. 32 (2025) 1–25. https://doi.org/10.1007/s11356-025-36310-w.
  52. A.H. Al-Mahfuz, A. Ghaemi, J. Environ. Eng. Sci. 19 (2024) 206–213. https://doi.org/10.1680/jenes.23.00096.
  53. Y. Liu, M. Yao, Z. Jin, Y. Zhang, npj Clean Water 8 (2025) 40. https://doi.org/10.1038/s41545-025-00453-7.
  54. R. Mirbagheri, D. Elhamifar, M. Shaker, Sci. Rep. 11 (2021) 23259. https://doi.org/10.1038/s41598-021-02699-w.
  55. A. El-Denglawey, M.F. Mubarak, H. Selim, Arab. J. Sci. Eng. 47 (2022) 455–476. https://doi.org/10.1007/s13369-021-05690-9.
  56. A. El Jery, H.S. Alawamleh, M.H. Sami, H.A. Abbas, S.S. Sammen, A. Ahsan, M. Imteaz, A.A. Shanableh, M. Shafiquzzaman, H. Osman, N. Al-Ansari, Sci. Rep. 14 (2024) 970. https://doi.org/10.1038/s41598-023-50937-0.
  57. M. Kanagalakshmi, S.G. Devi, P. Ananthi, A. Pius, in: Carbon Nanomater. Their Compos. Adsorb., Springer, 2024, pp. 135–154. https://doi.org/10.1007/978-3-031-48719-4-8.
  58. J.H. Lee, S.Y. Kwak, Appl. Surf. Sci. 467 (2019) 178–184. https://doi.org/10.1016/j.apsusc.2018.10.054.
  59. M. Lv, D. Li, Z. Zhang, B.E. Logan, G. Liu, M. Sun, C. Dai, Y. Feng, Sci. Total Environ. 757 (2021) 143717. https://doi.org/10.1016/j.scitotenv.2020.143717.
  60. L. Yin, K. Wang, L. Jiang, Y. Xi, Z. Xu, Z. Song, H. Zhou, RSC Adv. 15 (2025) 16337–16347. https://doi.org/10.1039/D5RA00872G.
  61. M.A. Diab, A.B. Ali, A. Abdulrahman, A. BaQais, M.I. Khan, A. Abduvokhidov, M. Karimov, O. Mukhitdinov, I. Mahariq, Surf. Interfaces 73 (2025) 107517. https://doi.org/10.1016/j.surfin.2025.107517.
  62. L.R. Rad, H. Faramarzi, M. Anbia, M. Irani, Sep. Purif. Technol. 339 (2024) 126597. https://doi.org/10.1016/j.seppur.2024.126597.
  63. S. Shenavaie asl, A. Pourahmad, S.R. Mansour, N. Sohrabi-Gilani, Results Chem. (2025) 102876. https://doi.org/10.1016/j.rechem.2025.102876.
  64. D. Ramutshatsha-Makhwedzha, M.L. Mavhungu, J. Baloyi, R. Mbaya, J. Iran. Chem. Soc. 22 (2025) 113–128. https://doi.org/10.1007/s13738-024-03135-2.
  65. M. Shaker, D. Elhamifar, New J. Chem. 44 (2020) 3445–3454. https://doi.org/10.1039/C9NJ06250E.
  66. S. Simsek, H.I. Ulusoy, J. Polym. Environ. 26 (2018) 1605–1612. https://doi.org/10.1007/s10924-017-1067-5.
  67. J.H. Lee, S.Y. Kwak, Appl. Surf. Sci. 467 (2019) 178–184. https://doi.org/10.1016/j.apsusc.2018.10.054.
  68. I.K. Rind, M.F. Lanjwani, A. Sarı, M. Tuzen, T.A. Saleh, Nano-Struct. Nano-Objects 39 (2024) 101283. https://doi.org/10.1016/j.nanoso.2024.101283.
  69. D. Chen, T. Awut, B. Liu, Y. Ma, T. Wang, I. Nurulla, e-Polymers 16 (2016) 313–322. https://doi.org/10.1515/epoly-2016-0043.
  70. Z. Heidarnezhad, A. Ghorbani-Choghamarani, Z. Taherinia, Nanoscale Adv. 6 (2024) 4360–4368. https://doi.org/10.1039/D4NA00414K.