One-pot three component synthesis of 2-amino-4H-chromenes under green and high efficient conditions
- Department of Organic Chemistry, Faculty of Chemisry, University of Kashan, Kashan, Iran, P.O. Box 8731753153.
- Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, Iran.
Abstract
A simple, mild and high efficient procedure for one pot three component synthesis of 2-amino 4-H chromene derivatives was studied. The reaction was performed in water using aryl aldehydes, malononitrile and resorcinol, phloroglucinol or naphthole in the presence of N-methyl D-glucamine (Meglumine) as a green high efficient catalyst. The reaction was studied in thermal, microwave (MW) and ultrasonic (US) conditions. Obtained results show that meglumine, as a green catalyst, has high efficiency in all reaction conditions and the yield of products (in all cases) is high to excellent. Environment friendly solvent and catalyst, short reaction times and high yield products are the advantageous of presented research.