Highly efficient synthesis of carboacyclic nucleosides catalyzed by zinc oxide in 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br)
- Department of Chemistry, Payame Noor University, P.O. Box 19395-3697, Tehran, Iran.
- Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran
- Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, 6541861841, Iran.
Abstract
Michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short reaction times.