Green and diastereoselective synthesis of trans-3-(5-methylisoxazol-3-yl)-3,4-dihydro-2H-naphtho[2,3-e][1,3]oxazines
- Chemistry Department, Malek-ashtar University of Technology, Shahin-shahr, 83145-115, Iran.
- Catalysis Division, Department of Chemistry, Faculty of Science, University of Isfahan, Isfahan 81746-7344, Iran.
- Department of Chemistry, Shahid Beheshti University, Evin, Tehran 1983963113, Iran.
Abstract
Reaction between aromatic aldehydes and 3âmethyl-1-phenyl-2-pyrazoline-5-one catalyzed by nano-SiO2/HClO4 in water under reflux provided a simple and efficient route for the synthesis of 4-((5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)(aryl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5-ol derivatives in high yields.