Melamine trisulfonic acid (MTSA) as an efficient catalyst for the synthesis of triazolo[1,2-a]indazole-triones and some 2H-indazolo[2,1-b]phthalazine-triones
- Faculty of Chemistry, University of Bu-Ali Sina, 65178, Hamedan, Iran.
- Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran.
- School of Pharmacy, University of Medical Sciences, Hamedan 65178, Iran.
- Organic Polymer Chemistry Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan, Iran.
- Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan, Iran.
Abstract
Melamine trisulfonic acid (MTSA) as an efficient heterogeneous catalyst has been used for the one-pot preparation of triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-1,6,11-trione derivatives by the three-component condensation reaction of urazoles or phthalhydrazide, dimedone or 1,3-cyclohexanedione, and aldehydes under solvent-free conditions in good to excellent yields and short reaction times.