Synthesis of 1,3,5-tri-substituted pyrazoles promoted by P2O5.SiO2
- Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
- Department of Chemistry, College of Science, Yazd University, P. O. Box 89195-741, Yazd. Iran.
- Department of Chemistry, College of Science, Yazd University, P.O.Box 89195-741, Yazd, I.R.Iran.
Abstract
Silica supported phosphorus pentoxide (P2O5·SiO2) is an efficient catalyst for synthesis of 1,3,5-substituted pyrazoles via the condensation of 1,3-diketones and hydrazines. Simplicity of procedure, mild condition, being solvent-free, high yields, and easy workup are some advantages of this protocol.