OICC Press International Journal of Biophotonics and Biomedical Engineering (IJBBE) 2980-9037 5 2 2025 12 31 Sonochemical Design and Characterization of 8-hydroxyquinoline Based Nano Metal Complexes as Promising Candidates for Biomedical Engineering 10.57647/ijbbe.2025.0502.12 EN Amir Safaralizadeh Department of Chemistry, Ta. C., Islamic Azad University, Tabriz, Iran Gholam Hossein Shahverdizadeh Department of Chemistry, Ta. C., Islamic Azad University, Tabriz, Iran; Industrial Nanotechnology Research Center, Ta. C., Islamic Azad University, Tabriz, Iran Samad Bavili Tabrizi Department of Chemistry, Ta. C., Islamic Azad University, Tabriz, Iran Masoud Moghadaszadeh Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Elnaz Ghasemi Department of Chemistry, Ta. C., Islamic Azad University, Tabriz, Iran Journal Article 2025 12 31 In this work, zinc-based nanocomplexes were synthesized via an ultrasonic-assisted method using varying concentrations of ligand solutions. The synthesis involved the gradual addition of aqueous zinc acetate to ligand solutions dissolved in ethanol, followed by ultrasonic irradiation to promote complex formation. Comprehensive characterization techniques including X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-Vis) spectroscopy, scanning electron microscopy (SEM), thermogravimetric analysis (Tg), differential thermal analysis (DTA), and nuclear magnetic resonance (NMR) spectroscopy were employed to investigate the structural, morphological, thermal, and chemical properties of the nanocomplexes. The results demonstrate that ultrasonic-assisted synthesis is a facile, efficient, and environmentally friendly approach for producing zinc nanocomplexes with tunable size and morphology. This study highlights the critical role of ligand concentration in controlling the physicochemical properties of the nanocomplexes, suggesting potential applications in catalysis, sensing, and biomedical fields.